Primary Biliary Cirrhosis

woman
Primary biliary cirrhosis is a chronic condition in which the bile ducts in your liver become inflamed and are slowly destroyed. PBC is thought to be caused by an autoimmune reaction, but what initiates the autoimmune destruction of the bile ducts is not known. When bile ducts are damaged, as in primary biliary cirrhosis, bile and other harmful substances can build up in the liver leading to irreversible scarring of liver tissue. Primary biliary cirrhosis affects women more often than men, and onset usually occurs between the ages of 40 and 60. Inhibiting the ASBT, which is responsible for recycling bile acids back to the liver, may mimic the effects of successful surgical approaches that reduce bile accumulation in the liver, thereby improving liver function and symptoms of disease. Inhibiting the ASBT, which is responsible for recycling bile acids back to the liver, may lower bile acid levels thereby improving liver function and symptoms of disease.

Lumena is currently conducting a Phase II clinical study of LUM001 in children with primary biliary cirrhosis | More Information »

Their Stories
"I've been waiting for a liver transplant for two years, nine months because they cannot control my itch, which is destroying my life."

- Gillian McLachlan, PBC patient