Primary Sclerosing Cholangitis

Primary sclerosing cholangitis is a disease that causes chronic inflammation and subsequent scarring of the bile ducts both inside and outside the liver. The blockage of the bile ducts prevents bile from being transported to the small intestines and gall bladder. The accumulation of bile in the liver leads to progressive liver damage, and eventually, liver failure. Primary sclerosing cholangitis affects approximately one in 10,000 people, and for reasons that are unknown, it impacts men twice as often as women. Liver transplant is the only known cure for primary sclerosing cholangitis, but transplant is typically reserved for people with severe liver damage, and does not prevent reoccurrence of the disease.

Bile acid levels are typically elevated in patients with primary scleroising cholangitis. Inhibiting the ASBT, which is responsible for recycling bile acids back to the liver, may lower bile acid levels thereby improving liver function and symptoms of disease.

Lumena is planning to evaluate LUM001 in a Phase II clinical study in adults with primary scleroising cholangitis. | More Information »

PSC Warrior
Sandi Pearlman

Sandi Pearlman shares her story of life with PSC and explains why there is a war to be won against this devastating disease. May part of her legacy be that she helped bring an end to this disease. Read her story here. Sadly, Sandi passed away on November 1, 2013. She was a beloved leader of the PSC community, implemented key programs for PSC Partners Seeking a Cure, a 501(c)3 foundation whose mission is deeply etched into its name. In her 38 years, she accomplished so much for the PSC community. PSC Partners will always keep her alive through the many contributions she made.